IMPAACT4HIV
Improving Advanced HIV Disease Outcomes with IMPAACT4HIV
The Improved Access to AHD Care and Treatment for HIV (IMPAACT4HIV) project is a Unitaid-funded project dedicated to enhancing access to optimal diagnosis, prevention, treatment, and innovative delivery mechanisms for Advanced HIV Disease (AHD).
Despite significant investments in HIV, mortality rates remain unacceptably high, with one-quarter of HIV-related deaths occurring in sub-Saharan Africa. In 2022, 630,000 HIV-related deaths were reported globally, half of which were due to advanced HIV disease. This condition disproportionately affects children under five, who are at high risk of severe illness and death.
AHD challenges in Sub-Saharan Africa (SSA)
Despite notable progress towards the 2030 targets, Advanced HIV Disease remains a challenge in Sub-Saharan Africa particularly affecting children and adolescents.
AHD affects 30% of ART naïve; 60% of people re-engaging in care.
60% (380,000) the deaths reported in 2022 were in SSA.
Leading causes of mortality are TB (30%), Cryptococcal Meningitis (15%) Severe bacterial infections.
Children (0-14) are disproportionately affected.
13% of deaths despite representing 4% of the disease burden.
Coverage of life-saving interventions remains suboptimal and inequitable in SSA, with gaps along the care cascade.
AHD diagnosis.
CD4 testing <30%; Limited OI testing: TB, Cryptococcal Meningitis & Histoplasmosis (Unknown)
Preventive treatment.
Limited prophylaxis: TPT among HIV- 58% 3; 3HP.
ART coverage.
Children (0-14): <50% vs Adults> 70%.
Pregnant women in SSA account for 50% of people not receiving ARTs.
Gender disparities: Men 78% vs Women 80%.
Pregnant women in SSA account for 50% of people not receiving ARTs.
Gender disparities: Men 78% vs Women 80%.
IMPAACT4HIV is dedicated to enhancing access to care and treatment for Advanced HIV Disease (AHD) across six high-burden African countries:
Côte d’Ivoire, Sierra Leone, the Democratic Republic of Congo (DRC), Nigeria, Mozambique, and South Africa.
Market-shaping interventions will negotiate pricing for new and existing tools, optimize innovation and responsive tool design, and improve access to and availability of affordable and high-quality diagnosis, prevention, and treatment options for those who need them.
Our goal is to effectively operationalize the STOPAIDS toolkit in these countries, ultimately improving health outcomes for those affected by advanced HIV disease.
IMPAACT4HIV Consortium
The IMPAACT4HIV consortium comprises six partner organisations providing global and country-focused technical support across six countries in SSA.
Key
IMPAACT4HIV is a Unitaid-funded project implemented by a consortium of six partners.
Unitaid
Role: Funder
Focus Countries:
Mozambique, South Africa, Nigeria, Cote D’Ivoire, The Democratic Republic of Congo (DRC) and Sierra Leone.
Focus Countries:
Mozambique, South Africa, Nigeria, Cote D’Ivoire, The Democratic Republic of Congo (DRC) and Sierra Leone.
The Aurum Institute
Role: Consortium Lead
Technical lead: Market Access, Communities and Civil Societies Engagements (CCSE).
Focus Countries:
South Africa, Mozambique, Nigeria
Technical lead: Market Access, Communities and Civil Societies Engagements (CCSE).
Focus Countries:
South Africa, Mozambique, Nigeria
Paediatric Adolescent Treatment Africa
Role: Communities and Civil Societies Engagements (CCSE).
Paediatrics advisory and technical support
Focus Countries:
South Africa, Mozambique, Cote D’Ivoire, Nigeria
Paediatrics advisory and technical support
Focus Countries:
South Africa, Mozambique, Cote D’Ivoire, Nigeria
Market Access Africa
Role: Market Access
Focus Countries:
Mozambique, South Africa, Nigeria, Cote D’Ivoire, The Democratic Republic of Congo (DRC) and Sierra Leone.
Focus Countries:
Mozambique, South Africa, Nigeria, Cote D’Ivoire, The Democratic Republic of Congo (DRC) and Sierra Leone.
Centre for Integrated Health Programs
Role: Delivery Partner, Nigeria
Focus Countries:
Nigeria
Focus Countries:
Nigeria
Drugs for Neglected Diseases Initiative
Role: Implementing Partner
Focus Countries:
The Democratic Republic of Congo (DRC)
Focus Countries:
The Democratic Republic of Congo (DRC)
Solidarité Thérapeutique et Initiatives pour la Santé
Role: Implementing Partner
Focus Countries:
Cote D’Ivoire, Sierra Leone
Focus Countries:
Cote D’Ivoire, Sierra Leone
